Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy
نویسندگان
چکیده
منابع مشابه
Hypericin-mediated photodynamic therapy induces apoptosis in K562 human leukemia cells through JNK pathway modulation
Hypericin (Hyp) is traditionally used as an antidepressant and antiviral agent. It selectively accumulates in spheroids and is also used as a photosensitizer in the photodynamic therapy of cancer. The present study aimed to investigate the cytotoxic effect of Hyp‑mediated photodynamic therapy (Hyp‑PDT) on cell growth and apoptosis of K562 leukemia cells, and to examine the underlying mechanisms...
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Photosensitizers (PSs) in photodynamic therapy (PDT) are, in most cases, administered systemically with preferential accumulation in malignant tissues; however, exposure of non-malignant tissues to PS may also be clinically relevant, when PS molecules affect the pro-apoptotic cascade without illumination. Hypericin (Hyp) as PS and its derivatives have long been studied, regarding their photodyn...
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Ovarian cancer is the fourth most frequent cause of cancer-related death in women in the United States. The currently recommended treatment is a combination of surgery followed by chemotherapy. However, ovarian cancer is characterized by the development of peritoneal micrometastases. These latter, hardly detectable by conventional method, are therefore suboptimally treated by standard surgery. ...
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Root canal disinfection is one of the main factors governing success of endodontic therapy. Antimicrobial photodynamic therapy (aPDT) is presented as a promising antimicrobial therapy that can eliminate microbiota present in infected root canal systems. In this study, a series of experiments investigated the effects of aPDT on cell viability and biofilm degradation ability of endopathogenic mic...
متن کاملCellular and molecular mechanisms of photodynamic hypericin therapy for nasopharyngeal carcinoma cells.
Hypericin-mediated photodynamic therapy (HY-PDT) has become a potential treatment for tumors and nonmalignant disorders. Some studies reported that HY-PDT could lead to apoptosis in some carcinoma cells. However, the molecular mechanism of HY-PDT remains unknown. In this study, we evaluated the molecular mechanisms of hypericin associated with light-emitting diode irradiation on the poorly diff...
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ژورنال
عنوان ژورنال: Molecular Cancer
سال: 2008
ISSN: 1476-4598
DOI: 10.1186/1476-4598-7-56